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	<title>human brain &#8211; News Agency nabakhabar</title>
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		<title>Reverse engineering the insect brain</title>
		<link>https://www.en.3danews.ir/news-header/69071/reverse-engineering-the-insect-brain</link>
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		<dc:creator><![CDATA[News Agency nabakhabar]]></dc:creator>
		<pubDate>Fri, 03 May 2024 19:03:30 +0000</pubDate>
				<category><![CDATA[news-header]]></category>
		<category><![CDATA[science and technology]]></category>
		<category><![CDATA[deep learning techniques]]></category>
		<category><![CDATA[human brain]]></category>
		<category><![CDATA[insect brain]]></category>
		<category><![CDATA[operate autonomously]]></category>
		<category><![CDATA[Reverse engineering]]></category>
		<guid isPermaLink="false">https://www.en.3danews.ir/?p=69071</guid>

					<description><![CDATA[<p>Until now, most efforts to create machines able to operate autonomously in the world have drawn on so-called deep learning techniques: a vastly expensive, computationally intensive suite of approaches that effectively attempt to replicate aspects of the human brain.</p>
<p>The post <a rel="nofollow" href="https://www.en.3danews.ir/news-header/69071/reverse-engineering-the-insect-brain">Reverse engineering the insect brain</a> appeared first on <a rel="nofollow" href="https://www.en.3danews.ir">News Agency nabakhabar</a>.</p>
]]></description>
										<content:encoded><![CDATA[<p><span class="td_btn td_btn_md td_default_btn" style="background-color: #e3e3e3; color: #000000;"><span class="dropcap dropcap3">U</span>ntil now, most efforts to create machines able to operate autonomously in the world have drawn on so-called deep learning techniques: a vastly expensive, computationally intensive suite of approaches that effectively attempt to replicate aspects of the human brain.</span></p>
<p>But UK technology startup Opteran is taking a different route, tapping into 600 million years of evolution to unravel and mimic the highly efficient navigational and decision-making abilities of insects.</p>
<p>Spun out from the University of Sheffield in 2020, Opteran &#8211; named after the Hymenoptera order of insects, which includes wasps, bees and ants &#8211; has now developed a commercially available product: the Opteran Mind &#8211; which it claims could help usher in a new era of higher performance autonomy at a fraction of the cost of existing approaches.</p>
<figure class="quote"></figure>
<p>Now employing 45 people, the company is growing rapidly, and last month announced a major partnership that will see its technology embedded in advanced warehouse robots developed by German autonomous picking and transportation robot manufacturer Safelog.</p>
<p>But as Opteran CEO David Rajan recently told The Engineer, this is just the beginning, and the company is already exploring and developing further commercial applications in sectors ranging from logistics and automotive, to mining, security and beyond.</p>
<p>The firm has its origins in research carried out at the University of Sheffield’s Department of Computer Science by co-founders Prof James Marshall and Dr Alex Cope.</p>
<p>Over the course of a decade, their group set about advancing the understanding of the structure and function of insect brains, using a host of techniques to figure out exactly how insects see the world, localise themselves in space, navigate over huge distances, and respond to all the uncertainty and chaos of the world around them.</p>
<p>By distilling these capabilities into a series of algorithms, the team arrived at a concept it refers to as “natural intelligence”: a potentially game-changing idea that it claims represents a vastly more sensible and efficient way of solving the autonomy challenge.</p>
<p>“Insects like honeybees have about a million neurons by comparison to around 86 billion in a human being, but the central systems are there,” said Rajan.  “They see the world, localise themselves in space and can even navigate up to 10 kilometers consuming just micro watts of power. If you really want to see state of the art autonomy, don’t go to California…..look at a garden.”</p>
<p>All of these capabilities are now in the process of being embedded in an actual product &#8211; the Opteran’ Mind- an edge computing solution composed of a series of insect-inspired algorithms. Crucially &#8211; and in stark contrast to most other efforts to crack the autonomy nut  &#8211; this technology runs with low-cost cameras and chips and doesn’t require training, infrastructure or connectivity to work.</p>
<p>The technology currently includes algortihms that enable machines to spatially navigate and know where they are in the world. Over the coming months, the team plans to add further capabilities including collision avoidance and &#8211; at some point next year &#8211;  decision making algorithms that will allow machines to prioritise tasks.</p>
<p>Explaining how Opteran Mind works in practice, the company’s chief product officer, Charlie Rance, contrasted it with the so-called SLAM (simultaneous localisation and mapping) approach to autonomous navigation, which is the most widely used  solution to the problem of robot navigation.</p>
<div class="fig-caption">
<h6 class="fig-image"><strong><img decoding="async" class="mb-0 aligncenter" src="https://www.theengineer.co.uk/media/stxpmuls/opteran-1.png?width=1002&amp;quality=80" /></strong></h6>
<h6 style="text-align: center;"><strong>Opteran&#8217;s technology is now being used on autonomous warehouse robots produced by Germany company Safelog <em>&#8211;</em></strong></h6>
</div>
<p>Using SLAM, a machine equipped with advanced cameras and huge amounts of processing power builds a highly accurate map and localises itself on that map at the same time. It’s a sophisticated technique that has been at the heart of autonomous development in recent years, but it’s not without its limitations: It’s expensive, it needs to be trained on huge amounts of data, and the maps it creates can fail or mislocalise if there are sudden, unexpected changes to the environment such as the lights being turned off or something being moved.</p>
<p>Opteran’s approach is fundamentally different. By mimicking the way an insect is able to find its way around using a brain the size of a pinhead and fewer than a million neurons, Opteran’s technology is able to solve this problem with, said Rance “the tiniest amount of compute and the lowest data footprint you can possibly think of.”</p>
<p>Alongside all of this, added Rajan, it’s also inherently better suited to dealing with the unpredictability of the  real word: “Things happen, things change: the weather is horrible, the lighting is bad, in a warehouse everything gets moved around all the time.  We’re operating  as nature can, instead of in this kind of engineered way of using sensors and compute to try and solve 80 per cent of the problem.”</p>
<p>What’s more, unlike existing systems, Opteran’s technology doesn’t need to be trained on vast amounts of data before being deployed. “We’re not gathering data to train a system in a datacenter,” said Rance. “The algorithms are innate, so they know how to move around the world on their own, they can respond to the dynamic variability, they adapt to the world as it’s happening around them.”</p>
<p>The Safelog application is a good illustration of this.  Typically, deploying an autonomous guided vehicle (AGV) into a warehouse takes a fair bit of setting up with operators having to painstakingly scan the entire facility and process huge amounts of data before the robots can be let loose on the warehouse floor. The set up using Opteran’s technology is, said Rance, orders of magnitude less onerous: “All it takes for them to do is to drive one robot at the speed that robot operates and off it goes. We’re essentially creating a solution that allows their AGVs to autonomously map in one shot, so it’s a very quick set up time and you can share that with the rest of your AGVs. We can remove fixed infrastructure, so we’re not using any kind of reflectors or QR codes or anything. And we’re keeping the system at a lower cost.”</p>
<div class="mceNonEditable embeditem" data-embed-url="https://www.youtube.com/watch?v=aLUAFMaGl3c" data-embed-height="408" data-embed-width="850" data-embed-constrain="true"><iframe title="Opteran &amp; SAFELOG: A vision only alternative to SLAM" src="https://www.youtube.com/embed/aLUAFMaGl3c?feature=oembed" width="725" height="408" frameborder="0" allowfullscreen="allowfullscreen" data-mce-fragment="1"></iframe></div>
<p>&nbsp;</p>
<p>Alongside the Safelog deal, the company also has a number of other ongoing commercial applications which, for the time being, are subject to client confidentiality agreements. However, Rajan told The Engineer that these include an application on an indoor security drone for the consumer market, as well as use of the technology in the mining and automotive sectors. Whilst the range of potential application areas is almost unlimited, Rajan stressed that there are some applications that the company is keen to avoid. “We are not in favor of kinetic applications”, he said, “we’ve already turned down projects in the drone industry that would have been kinetic.”</p>
<p>The company is now very consciously harvesting the low-hanging fruit, but its longer-term ambitions are huge: “The real opportunity here is every single machine that moves could have an Opteran mind inside,” said Rajan. “That means all the humanoid robots, all the vacuum cleaners, all the lawn mowers, all the warehouse robots, all the drones. That’s the opportunity in front of us: full general purpose autonomy inside every machine that moves on the planet. We want to be the autonomy company, the company that enables machines to move around the whole world with their own brain. That’s our ambition. We’re building the brain for everybody else’s brawn.”</p>
<p>The post <a rel="nofollow" href="https://www.en.3danews.ir/news-header/69071/reverse-engineering-the-insect-brain">Reverse engineering the insect brain</a> appeared first on <a rel="nofollow" href="https://www.en.3danews.ir">News Agency nabakhabar</a>.</p>
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		<title>I tried a 2-week negativity fast. Here’s how it went</title>
		<link>https://www.en.3danews.ir/news-header/68758/i-tried-a-2-week-negativity-fast-heres-how-it-went</link>
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		<dc:creator><![CDATA[News Agency nabakhabar]]></dc:creator>
		<pubDate>Sun, 21 Apr 2024 23:35:20 +0000</pubDate>
				<category><![CDATA[health]]></category>
		<category><![CDATA[news-header]]></category>
		<category><![CDATA[Anthony Iannarino]]></category>
		<category><![CDATA[human brain]]></category>
		<category><![CDATA[Netflix series]]></category>
		<category><![CDATA[news]]></category>
		<category><![CDATA[The Negativity Fast]]></category>
		<guid isPermaLink="false">https://www.en.3danews.ir/?p=68758</guid>

					<description><![CDATA[<p>Whether you turn on the news or attempt to unwind with a Netflix series, a lot of the messages in today’s world are negative. It’s easy to become immune to the heaviness, and you may not realize how much its constant drum beat impacts you. That’s because the human brain is wired to focus on the negative. It’s tied to survival.</p>
<p>The post <a rel="nofollow" href="https://www.en.3danews.ir/news-header/68758/i-tried-a-2-week-negativity-fast-heres-how-it-went">I tried a 2-week negativity fast. Here’s how it went</a> appeared first on <a rel="nofollow" href="https://www.en.3danews.ir">News Agency nabakhabar</a>.</p>
]]></description>
										<content:encoded><![CDATA[<div class="content-chunk" data-testid="content-chunk">
<p><span class="td_btn td_btn_md td_default_btn" style="background-color: #f7f7f7; color: #000000;"><span class="dropcap dropcap3">W</span>hether you turn on the news or attempt to unwind with a Netflix series, a lot of the messages in today’s world are negative. It’s easy to become immune to the heaviness, and you may not realize how much its constant drum beat impacts you. That’s because the human brain is wired to focus on the negative. It’s tied to survival.</span></p>
</div>
<div class="content-chunk" data-testid="content-chunk">
<p>“Our seven dominant emotions are anger, contempt, fear, disgust, happiness, sadness, and surprise,” says Anthony Iannarino, author of <em>The Negativity Fast: Proven Techniques to Increase Positivity, Reduce Fear, and Boost Success</em>. “Five dominant emotions are negative, with happiness the only positive one, unless the surprise happens to be positive.”</p>
<p>Iannarino didn’t realize how negativity impacted his life until a mentor told him, “You know, you’re really angry. All these things that you’re worried about? You can’t do anything about them. The best thing you can do is just let all this go and try to take care of your family.”</p>
<h3 class="wp-block-heading"><strong>HOW TO GO ON A NEGATIVITY FAST</strong></h3>
<p>Positivity is a choice, and it’s possible to spend more time in a positive state versus a negative one, says Iannarino. While it took six months, he finally took his mentor’s advice, deciding to remove all the negative sources in his life for 30 days.</p>
</div>
<div class="content-chunk" data-testid="content-chunk">
<p>“I got rid of every single magazine, newspaper, and book,” he recalls. “I started to remove some people in my life that I felt were causing me to be more negative than positive. I started looking around at everything that was negative.”</p>
<p>At the end of 30 days, Iannarino liked the results so much that he did another 30 days and then another. During his third 30-day negativity fast, he only consumed positive information, such as reading content by Stephen Covey, Brian Tracy, and Les Brown. “I was blasting out all the negative that I had put into my mind for many, many years, and it worked really well for me,” he says.</p>
<p>Iannarino also leaned on the work of Albert Ellis, founder of Rational Emotive Behavior Therapy. Ellis taught the ABC theory, which includes an activating event, your belief about what it means, and the consequences of how you react to it.</p>
</div>
<div class="content-chunk" data-testid="content-chunk">
<p>“If somebody cuts you off in traffic, for example, you can believe that they have road rage and they’re a terrible person or reckless, or you can believe that they could be rushing home because somebody was sick or they are under some sort of duress,” says Iannarino. “If you can change the belief, then you won’t be triggered anymore. It’s one of the more powerful things that you can do when you’re on a negativity fast.”</p>
<p>Another tool that helped Iannarino purge negativity was to look at his mortality. The average lifespan in the United States is 78.2 years, which boils down to 4,108 weeks. Iannarino uses a countdown app that tells him how many weeks he has left.</p>
<p>“I’m close to about 1,300,” he says. “People often think that’s morbid. Well, I’m here for a short time. You should do everything that you want to do and try to make the best contribution that you can while you’re here.”</p>
</div>
<div class="content-chunk" data-testid="content-chunk">
<h3 class="wp-block-heading"><strong>MY NEGATIVITY FAST</strong></h3>
<p>Positivity sounds, well, positive, so I decided to tip the daily scale in its favor for a week to see what would happen. I started with the news. I noticed that the morning news shows I watched while enjoying my coffee were focused on fear-mongering. And at night, I usually watch ABC’s <em>World News Tonight with David Muir</em> on weekday evenings. While the broadcast always ends with an upbeat story, the reporting in the first 25 minutes is mostly concerning.</p>
<p>I switched out the morning news with a walk and an uplifting podcast, such as <em>Happier with Gretchen Rubin</em> or <em>The Moth Radio Hour.</em> I also learned I could visit <em>World News Tonight’s</em> website and watch their positive news segments without having to sit through the bad first.</p>
<p>When I wanted a news fix, I did a quick scan of the headlines on neutral sources like NPR and Associated Press. Iannarino told me not to worry about missing anything important.</p>
</div>
<div class="content-chunk" data-testid="content-chunk">
<p>“This is the one concern that people have when I suggest getting rid of the things you watch,” he says. “They wonder, ‘How am I going to know what’s going on?’ I promise, everybody’s going to be talking about it, and they’re going to share it with you. They’ll still try to help you understand that there are bad things happening in the world.”</p>
<p>While I didn’t consider myself a negative person, I also realized I am a regular complainer, especially low-grade things like finding fault or comparing. I’m not alone, says Iannarino.</p>
<p>“Humans complain a lot and often don’t recognize they’re doing it,” he says. “It makes you more anxious and stressed. It can cause you to have other mental problems like depression. The antidote is gratitude.”</p>
</div>
<div class="content-chunk" data-testid="content-chunk">
<p>Iannarino recommended that I adopt the “three blessings” exercise by Martin Seligman, who is often called the father of positive psychology. Each day, write down three things that went well for you.</p>
<p>“Seligman’s research said it’s more powerful than pharmaceuticals and can keep you from being anxious, stressed, and depressed for as long as six months,” says Iannarino. “When you start looking back at what you wrote, you start to realize a lot of good things happen to you all the time.”</p>
<p>I did my negativity fast before Christmas, and the stress I usually feel about getting everything done didn’t arise this year. The three blessings practice helped me realize I have much to be thankful for, which made me more patient with others. The ABC Theory helped me avoid jumping to conclusions.</p>
</div>
<div class="content-chunk" data-testid="content-chunk">
<p>By the end of the first week, I felt calmer, so I kept it going for another week. I was surprised at how just two weeks of avoiding negativity changed what I want to consume. For example, a friend recommended watching <em>The Bear</em>. When I tuned into the Hulu series, I found the family arguments and drama overwhelming. The dialogue and violence felt like an assault on me, so I decided to turn it off.</p>
<p>Iannarino has been on a negativity fast for more than two decades. I am keeping it going, too, being more mindful of what I consume. Iannarino told me that a lot of people choose to continue.</p>
<p>“Going on a negativity fast will help you be a lot less angry, stressed, and anxious,” he says. “You’ll feel like you have greater control of what’s going on in your life.”</p>
</div>
<p>The post <a rel="nofollow" href="https://www.en.3danews.ir/news-header/68758/i-tried-a-2-week-negativity-fast-heres-how-it-went">I tried a 2-week negativity fast. Here’s how it went</a> appeared first on <a rel="nofollow" href="https://www.en.3danews.ir">News Agency nabakhabar</a>.</p>
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		<title>No, the human brain did not shrink 3,000 years ago: research</title>
		<link>https://www.en.3danews.ir/news-header/58153/no-the-human-brain-did-not-shrink-3000-years-ago-research</link>
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		<dc:creator><![CDATA[News Agency nabakhabar]]></dc:creator>
		<pubDate>Sat, 06 Aug 2022 11:44:11 +0000</pubDate>
				<category><![CDATA[news-header]]></category>
		<category><![CDATA[science and technology]]></category>
		<category><![CDATA[evolutionary reduction]]></category>
		<category><![CDATA[great empires]]></category>
		<category><![CDATA[human brain]]></category>
		<category><![CDATA[urban societies]]></category>
		<guid isPermaLink="false">https://www.en.3danews.ir/?p=58153</guid>

					<description><![CDATA[<p>Did the 12th century B.C.E.—a time when humans were forging great empires and developing new forms of written text—coincide with an evolutionary reduction in brain size? Think again, says a UNLV-led team of researchers who refute a hypothesis that's growing increasingly popular among the science community.</p>
<p>The post <a rel="nofollow" href="https://www.en.3danews.ir/news-header/58153/no-the-human-brain-did-not-shrink-3000-years-ago-research">No, the human brain did not shrink 3,000 years ago: research</a> appeared first on <a rel="nofollow" href="https://www.en.3danews.ir">News Agency nabakhabar</a>.</p>
]]></description>
										<content:encoded><![CDATA[<p><span class="td_btn td_btn_md td_default_btn" style="background-color: #e0e0e0; color: #000000;"><span class="dropcap dropcap3">D</span>id the 12th century B.C.E.—a time when humans were forging great empires and developing new forms of written text—coincide with an evolutionary reduction in brain size? Think again, says a UNLV-led team of researchers who refute a hypothesis that&#8217;s growing increasingly popular among the science community.</span></p>
<section class="article-banner first-banner ads-336x280">
<div id="div-gpt-ad-1449240174198-2" data-google-query-id="CO7EkpaEsvkCFTCkJwIdzeoC8Q">
<div id="google_ads_iframe_/4988204/Phys_Story_InText_Box_0__container__">Last year, a group of scientists made headlines when they concluded that the human brain shrank during the transition to modern urban societies about 3,000 years ago because, they said, our ancestors&#8217; ability to store information externally in social groups decreased our need to maintain large brains. Their hypothesis, which explored decades-old ideas on the evolutionary reduction of modern human brain size, was based on a comparison to evolutionary patterns seen in ant colonies.</div>
</div>
</section>
<p>Not so fast, said UNLV anthropologist Brian Villmoare and Liverpool John Moores University scientist Mark Grabowski.</p>
<p>In a new paper published last week in <i>Frontiers in Ecology and Evolution</i>, the UNLV-led team analyzed the dataset that the research group from last year&#8217;s study used and dismissed their findings.</p>
<p>&#8220;We were struck by the implications of a substantial reduction in modern human brain size roughly 3,000 years ago, during an era of many important innovations and historical events—the appearance of Egypt&#8217;s the New Kingdom, the development of Chinese script, the Trojan War, and the emergence of the Olmec civilization, among many others,&#8221; Villmoare said.</p>
<p>&#8220;We re-examined the dataset from DeSilva et al. and found that human brain size has not changed in 30,000 years, and probably not in 300,000 years,&#8221; Villmoare said. &#8220;In fact, based on this dataset, we can identify no reduction in brain size in modern humans over any time period since the origins of our species.&#8221;</p>
<h3><b>Key takeaways</b></h3>
<p>The UNLV research team questioned several of the hypotheses that DeSilva et. al gleaned from a dataset of nearly 1,000 early human fossil and museum specimens, including:</p>
<ul>
<li>The UNLV team says the rise of agriculture and complex societies occurred at different times around the globe—meaning there should be variation in the timing of skull changes seen in different populations. However, DeSilva&#8217;s dataset sampled only 23 crania from the timeframe critical to the brain shrinkage hypothesis and lumped together specimens from locations including England, China, Mali, and Algeria.</li>
<li>The dataset is heavily skewed because more than half of the 987 skulls examined represent only the last 100 years of a 9.8-million-year span of time—and therefore don&#8217;t give scientists a good idea of how much cranial size has changed over time.</li>
<li>Multiple hypotheses on causes of reduction in modern human brain size need to be reassessed if human brains haven&#8217;t actually changed in size since the arrival of our species.</li>
</ul>
<p>The post <a rel="nofollow" href="https://www.en.3danews.ir/news-header/58153/no-the-human-brain-did-not-shrink-3000-years-ago-research">No, the human brain did not shrink 3,000 years ago: research</a> appeared first on <a rel="nofollow" href="https://www.en.3danews.ir">News Agency nabakhabar</a>.</p>
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		<title>Study unveils new clonal relations in the mouse brain</title>
		<link>https://www.en.3danews.ir/news-header/55157/study-unveils-new-clonal-relations-in-the-mouse-brain</link>
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		<dc:creator><![CDATA[News Agency nabakhabar]]></dc:creator>
		<pubDate>Fri, 25 Mar 2022 14:44:55 +0000</pubDate>
				<category><![CDATA[news-header]]></category>
		<category><![CDATA[science and technology]]></category>
		<category><![CDATA[clonal relations]]></category>
		<category><![CDATA[glial cells]]></category>
		<category><![CDATA[human brain]]></category>
		<category><![CDATA[mouse brain]]></category>
		<category><![CDATA[neuroepithelial progenitor cells]]></category>
		<category><![CDATA[neurons]]></category>
		<guid isPermaLink="false">https://www.en.3danews.ir/?p=55157</guid>

					<description><![CDATA[<p>The human brain and the brain of other mammals contain numerous populations of specialized cells with unique functions, molecular structures and characteristics. These cells originate from a thin layer of neuroepithelial progenitor cells, cells that can divide themselves into specific populations of neurons and glial cells.</p>
<p>The post <a rel="nofollow" href="https://www.en.3danews.ir/news-header/55157/study-unveils-new-clonal-relations-in-the-mouse-brain">Study unveils new clonal relations in the mouse brain</a> appeared first on <a rel="nofollow" href="https://www.en.3danews.ir">News Agency nabakhabar</a>.</p>
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										<content:encoded><![CDATA[<p><span class="td_btn td_btn_md td_default_btn" style="background-color: #e0e0e0; color: #000000;"><span class="dropcap dropcap3">T</span>he human brain and the brain of other mammals contain numerous populations of specialized cells with unique functions, molecular structures and characteristics. These cells originate from a thin layer of neuroepithelial progenitor cells, cells that can divide themselves into specific populations of neurons and glial cells.</span></p>
<p>In recent years, technological advances have allowed neuroscientists to study the diverse cell populations in the brain more in-depth. While this has shed light on the function of some cell populations and their molecular composition, the relationship between mature cell populations and progenitor cells is still poorly understood.</p>
<p>Researchers at Karolinska Institute, KTH Royal Institute of Technology and Stockholm University have recently carried out a study aimed at better understanding the clonal relations between cells in the mouse brain. Their findings, published in <i>Nature Neuroscience</i>, were collected using a new approach they developed that combines single-cell and spatial transcriptomics with clonal barcoding, two different methods used to conduct neuroscience studies.</p>
<p>&#8220;Our lab studies the potential of neural stem cells to generate a wide variety of cell types, which is important to understand normal brain development and could be exploited to regenerate lost cells in neurological diseases,&#8221; Michael Ratz, one of the researchers who carried out the study, told Medical Xpress.</p>
<p>To better understand the potential of stem cells as generators of different cell populations, the researchers used an approach known as &#8220;fate mapping&#8221; or &#8220;clonal tracking.&#8221; This is a powerful technique that allows scientists to identify the &#8220;progeny&#8221; of a single cell and to reconstruct its developmental history (i.e., ancestry).</p>
<p>&#8220;These methods have led to fundamental insights about tissue development and have been used for many years, but they are limited in their ability to study many cells at the same time due to their reliance on microscopy which can only distinguish a few colors (usually &lt;5) at once,&#8221; Ratz said. &#8220;We wanted to establish an approach that matches the complexity of the nervous system, by converting the problem of fate mapping into a form that can be read out by modern high-throughput sequencing methods.&#8221;</p>
<p>Past studies have found that cells in the mammalian brain can differ significantly in shape, function and spatial location. However, traditional methods to study the brain did not allow researchers to gather extensive information about individual cells.</p>
<p>An interesting metaphor that is sometimes used to describe this previous lack of insight about individual cells is the smoothie vs. fruit salad analogy. Essentially, previously neuroscientists were only able to observe large sections of brain tissues as a single, homogenous mixture (i.e., resembling a smoothie). This prevented them from learning more about specific cells in these sections of brain tissue (i.e., individual fruits inside the smoothie).</p>
<p>&#8220;In recent years, technological advances allowed us to look at individual cells at the mRNA level, to study the cellular composition of brain tissue and how cells that malfunction can lead to disease,&#8221; Ratz explained. &#8220;One such method is single-cell transcriptomics, where individual cells are extracted from tissue and the sequences of thousands of mRNA molecules present in a single cell are sequenced while spatial transcriptomics achieves the same, but with intact tissue sections which preserves critical information about an individual cells&#8217; location in a tissue.&#8221;</p>
<p>In their study, Ratz and his colleagues used genetic barcodes to characterize individual stem (progenitor) cells in the mouse brain. As these barcodes are inherited by daughter cells during brain development, they allowed them to study the clonal relationships between the cells and derive their phenotype profiles.</p>
<p>Subsequently, the researchers generated barcoding reagents and characterized the performance of these reagents in vivo (i.e., in the brain tissue of live mice). Their results could be very valuable for the neuroscientific community and could soon inform new studies investigating cell clonal relations more in-depth. In the future, their experimental approach could also be used to conduct other studies examining specific cell populations or the relations between progenitor and daughter cells.</p>
<p>&#8220;We used this technology to discover unique clonal features of microglia, the brain&#8217;s immune cells that play an important role in neurodegenerative diseases, such as the large groups of cells an individual precursor cell forms and their widespread migration across large brain areas,&#8221; Ratz added. &#8220;The tool we developed sheds new light on the molecular profiles underlying those cellular behaviors during normal development and could be adapted to study such microglia features in neurological diseases.&#8221;</p>
<p>The post <a rel="nofollow" href="https://www.en.3danews.ir/news-header/55157/study-unveils-new-clonal-relations-in-the-mouse-brain">Study unveils new clonal relations in the mouse brain</a> appeared first on <a rel="nofollow" href="https://www.en.3danews.ir">News Agency nabakhabar</a>.</p>
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